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DNA-Protein Cross-link Formation in Nucleosome Core Particles Treated with Methyl Methanesulfonate
N7-Methyl-2′-deoxyguanosine (MdG) is the major damage product in DNA produced by methylating agents, but it often thought to be nontoxic and nonmutagenic. MdG is chemically unstable. An abasic site (AP) is the major product produced from MdG under physiologically relevant conditions. AP formation is...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Res Toxicol |
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| Κύριοι συγγραφείς: | , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2019
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6803050/ https://ncbi.nlm.nih.gov/pubmed/31532638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00314 |
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