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DNA-Protein Cross-link Formation in Nucleosome Core Particles Treated with Methyl Methanesulfonate
N7-Methyl-2′-deoxyguanosine (MdG) is the major damage product in DNA produced by methylating agents, but it often thought to be nontoxic and nonmutagenic. MdG is chemically unstable. An abasic site (AP) is the major product produced from MdG under physiologically relevant conditions. AP formation is...
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| Publicado no: | Chem Res Toxicol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6803050/ https://ncbi.nlm.nih.gov/pubmed/31532638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00314 |
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