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Constitutively Active Artemis Nuclease Recognizes Structures Containing Single-Stranded DNA Configurations

The Artemis nuclease recognizes and endonucleolytically cleaves at single-stranded to double-stranded DNA (ss/dsDNA) boundaries. It is also a key enzyme in the non-homologous end joining (NHEJ) DNA double-strand break repair pathway. Previously, a truncated form, Artemis-413, was developed that is c...

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Foilsithe in:DNA Repair (Amst)
Main Authors: Pannunzio, Nicholas R., Lieber, Michael R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6801081/
https://ncbi.nlm.nih.gov/pubmed/31377101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2019.102676
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