DNA-PKcs Regulates a Single-stranded DNA Endonuclease Activity of Artemis

Human nuclease Artemis belongs to the metallo-beta-lactamase protein family. It acquires double-stranded DNA endonuclease activity in the presence of DNA-PKcs. This double-stranded DNA endonuclease activity is critical for opening DNA hairpins in V(D)J recombination and is thought to be important fo...

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Detalhes bibliográficos
Main Authors: Gu, Jiafeng, Li, Sicong, Zhang, Xiaoshan, Wang, Ling-Chi, Niewolik, Doris, Schwarz, Klaus, Legerski, Randy J., Zandi, Ebrahim, Lieber, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847011/
https://ncbi.nlm.nih.gov/pubmed/20117966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2010.01.001
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