Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence

The double-strand DNA break repair pathway, non-homologous DNA end joining (NHEJ), is distinctive for the flexibility of its nuclease, polymerase and ligase activities. Here we find that the joining of ends by XRCC4-ligase IV is markedly influenced by the terminal sequence, and a steric hindrance mo...

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Detaylı Bibliyografya
Asıl Yazarlar: Gu, Jiafeng, Lu, Haihui, Tsai, Albert G., Schwarz, Klaus, Lieber, Michael R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2007
Konular:
Nucleic Acid Enzymes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034460/
https://ncbi.nlm.nih.gov/pubmed/17717001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm579
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