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Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis

The rise in incidence and prevalence of eosinophilic esophagitis (EoE) since the 1990s has promoted investigations into its pathogenesis, natural history, and management. Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants...

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Podrobná bibliografie
Vydáno v:Curr Opin Immunol
Hlavní autoři: Lyles, John, Rothenberg, Marc
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800613/
https://ncbi.nlm.nih.gov/pubmed/31132551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2019.04.004
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