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Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis

The rise in incidence and prevalence of eosinophilic esophagitis (EoE) since the 1990s has promoted investigations into its pathogenesis, natural history, and management. Identified genetic variants in FLG, DSG1, CAPN14, SPINK5, and SPINK7 link EoE to epithelial barrier dysfunction, whereas variants...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Curr Opin Immunol
Main Authors: Lyles, John, Rothenberg, Marc
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800613/
https://ncbi.nlm.nih.gov/pubmed/31132551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2019.04.004
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