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A Pharmacokinetic Natural Product-Disease-Drug Interaction: A Double Hit of Silymarin and Nonalcoholic Steatohepatitis on Hepatic Transporters in a Rat Model

Patients with nonalcoholic steatohepatitis (NASH) exhibit altered hepatic protein expression of metabolizing enzymes and transporters and altered xenobiotic pharmacokinetics. The botanical natural product silymarin, which has been investigated as a treatment of NASH, contains flavonolignans that inh...

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Publicat a:J Pharmacol Exp Ther
Autors principals: Montonye, Michelle L., Tian, Dan-Dan, Arman, Tarana, Lynch, Katherine D., Hagenbuch, Bruno, Paine, Mary F., Clarke, John D.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6800447/
https://ncbi.nlm.nih.gov/pubmed/31420525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.260489
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