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3012 Functional consequences of pravastatin isomerization on OATP1B1-mediated transport

OBJECTIVES/SPECIFIC AIMS: In the present study, we examined the functional consequences of 3α-PVA on OATP1B1-mediated PVA transport. To elucidate this, we determined the effect of SLCO1B1 genotype on PVA transport and the role of 3αPVA as a competitive inhibitor of OATP1B1, which could serve as anot...

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Pubblicato in:J Clin Transl Sci
Autori principali: Wagner, Jonathan, Ruggiero, Melissa, Steven Leeder, J., Hagenbuch, Bruno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cambridge University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799086/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/cts.2019.243
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