Dynamic Imprinting of the Treg Cell-Specific Epigenetic Signature in Developing Thymic Regulatory T Cells

Regulatory T (Treg) cells mainly develop within the thymus and arise from CD25(+)Foxp3(−) (CD25(+) TregP) or CD25(−)Foxp3(+) (Foxp3(+) TregP) Treg cell precursors resulting in Treg cells harboring distinct transcriptomic profiles and complementary T cell receptor repertoires. The stable and long-ter...

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Udgivet i:Front Immunol
Main Authors: Herppich, Susanne, Toker, Aras, Pietzsch, Beate, Kitagawa, Yohko, Ohkura, Naganari, Miyao, Takahisa, Floess, Stefan, Hori, Shohei, Sakaguchi, Shimon, Huehn, Jochen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6797672/
https://ncbi.nlm.nih.gov/pubmed/31681278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02382
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