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Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases

Naturally arising regulatory CD4(+) T (Treg) cells, which specifically express the transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a T-cell subpopulation specialized for immune suppression, playing a key role in maintaining immunological self-tolerance and home...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Res
Main Authors: Ohkura, Naganari, Sakaguchi, Shimon
Format: Artigo
Jezik:Inglês
Izdano: Springer Singapore 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7264322/
https://ncbi.nlm.nih.gov/pubmed/32367041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-020-0324-7
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