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Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and IL-2. However, unlike Foxp3(+) naturally occurring Tregs, such in vitro induced Tregs (iTregs) are functionally unstable mainly because of inco...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Mikami, Norihisa, Kawakami, Ryoji, Chen, Kelvin Y., Sugimoto, Atsushi, Ohkura, Naganari, Sakaguchi, Shimon
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275710/
https://ncbi.nlm.nih.gov/pubmed/32414925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922600117
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