Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and IL-2. However, unlike Foxp3(+) naturally occurring Tregs, such in vitro induced Tregs (iTregs) are functionally unstable mainly because of inco...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Mikami, Norihisa, Kawakami, Ryoji, Chen, Kelvin Y., Sugimoto, Atsushi, Ohkura, Naganari, Sakaguchi, Shimon
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7275710/
https://ncbi.nlm.nih.gov/pubmed/32414925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1922600117
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