The Treg-Specific Demethylated Region Stabilizes Foxp3 Expression Independently of NF-κB Signaling

Regulatory T cells (Tregs) obtain immunosuppressive capacity by the upregulation of forkhead box protein 3 (Foxp3), and persistent expression of this transcription factor is required to maintain their immune regulatory function and ensure immune homeostasis. Stable Foxp3 expression is achieved throu...

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Detalhes bibliográficos
Main Authors: Schreiber, Lisa, Pietzsch, Beate, Floess, Stefan, Farah, Carla, Jänsch, Lothar, Schmitz, Ingo, Huehn, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3914969/
https://ncbi.nlm.nih.gov/pubmed/24505473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088318
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