Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

BACKGROUND: The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and transgenic...

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Detaylı Bibliyografya
Yayımlandı:Mol Neurodegener
Asıl Yazarlar: Huynh, Tien-Phat V., Wang, Chao, Tran, Ainsley C., Tabor, G. Travis, Mahan, Thomas E., Francis, Caroline M., Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E., Ulrich, Jason D., Holtzman, David M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796484/
https://ncbi.nlm.nih.gov/pubmed/31623648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0337-1
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