Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

BACKGROUND: The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and transgenic...

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Publicado en:Mol Neurodegener
Autores principales: Huynh, Tien-Phat V., Wang, Chao, Tran, Ainsley C., Tabor, G. Travis, Mahan, Thomas E., Francis, Caroline M., Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E., Ulrich, Jason D., Holtzman, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796484/
https://ncbi.nlm.nih.gov/pubmed/31623648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0337-1
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