Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

BACKGROUND: The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and transgenic...

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Dettagli Bibliografici
Pubblicato in:Mol Neurodegener
Autori principali: Huynh, Tien-Phat V., Wang, Chao, Tran, Ainsley C., Tabor, G. Travis, Mahan, Thomas E., Francis, Caroline M., Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E., Ulrich, Jason D., Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796484/
https://ncbi.nlm.nih.gov/pubmed/31623648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0337-1
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