ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model

OBJECTIVE: Apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer`s disease with the ε4 allele increasing risk in a dose-dependent fashion. In addition to ApoE4 playing a crucial role in amyloid-β deposition, recent evidence suggests that it also plays an impo...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Litvinchuk, Alexandra, Huynh, Tien-Phat V., Shi, Yang, Jackson, Rosemary J., Finn, Mary Beth, Manis, Melissa, Francis, Caroline M., Tran, Ainsley, Sullivan, Patrick M., Ulrich, Jason D., Hyman, Bradley T., Cole, Tracy, Holtzman, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260038/
https://ncbi.nlm.nih.gov/pubmed/33550655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.26043
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