ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model

OBJECTIVE: Apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late-onset Alzheimer`s disease with the ε4 allele increasing risk in a dose-dependent fashion. In addition to ApoE4 playing a crucial role in amyloid-β deposition, recent evidence suggests that it also plays an impo...

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Pubblicato in:Ann Neurol
Autori principali: Litvinchuk, Alexandra, Huynh, Tien-Phat V., Shi, Yang, Jackson, Rosemary J., Finn, Mary Beth, Manis, Melissa, Francis, Caroline M., Tran, Ainsley, Sullivan, Patrick M., Ulrich, Jason D., Hyman, Bradley T., Cole, Tracy, Holtzman, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8260038/
https://ncbi.nlm.nih.gov/pubmed/33550655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.26043
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