Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model

BACKGROUND: The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the periphery. Studies using APOE knock-in and transgenic...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Mol Neurodegener
Главные авторы: Huynh, Tien-Phat V., Wang, Chao, Tran, Ainsley C., Tabor, G. Travis, Mahan, Thomas E., Francis, Caroline M., Finn, Mary Beth, Spellman, Rebecca, Manis, Melissa, Tanzi, Rudolph E., Ulrich, Jason D., Holtzman, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796484/
https://ncbi.nlm.nih.gov/pubmed/31623648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-019-0337-1
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы