P11.60 Neurosurgical delivery of the poly ADP ribose polymerase-1 inhibitor olaparib from a thermo-responsive biodegradable paste potentiates radiotherapy and prolongs survival

BACKGROUND: There has been considerable interest in repurposing the poly ADP ribose polymerase inhibitor and purported radiosensitiser olaparib (Lynparza), with a recent dose escalation study of olaparib plus temozolomide in recurrent GBM showing good tolerance. Due to systemic therapy-associated ca...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Smith, S, Serra, R, Rowlinson, J, Gorelick, N, Veal, G, Shakesheff, K, Brem, H, Grundy, R, Tyler, B, Rahman, R
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
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Poster Presentations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6796133/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz126.206
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