SCDT-10. OVERALL SURVIVAL IN AN ORTHOTOPIC MALIGNANT GLIOMA MODEL IS SIGNIFICANTLY PROLONGED BY NEUROSURGICAL DELIVERY OF PLGA/PEG INTERSTITIAL CHEMOTHERAPY PASTE

INTRODUCTION: The blood brain barrier is a critical limiting step to achieving therapeutic CNS drug concentrations. We have developed a poly(lactic-co-glycolic acid)/poly(ethylene glycol) (PLGA/PEG)-based platform technology to interstitially deliver multiple chemotherapy agents from a single thermo...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Smith, Stuart, Tyler, Betty, Gould, Toby, Veal, Gareth, Ritchie, Alison, Berry, Phillip, Otto, Annette, Rowlinson, Jonathan, Choi, John, Skuli, Nicolas, Shakesheff, Kevin, Brem, Henry, Grundy, Richard, Rahman, Ruman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692870/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1093
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