Neurosurgical delivery of the poly ADP ribose polymerase-1 inhibitor olaparib from a thermo-responsive biodegradable paste potentiates radiotherapy and prolongs survival

There has been considerable interest in repurposing the poly ADP ribose polymerase inhibitor and purported radiosensitiser olaparib (Lynparza), with a recent dose escalation study of olaparib plus temozolomide in recurrent GBM showing good tolerance. Due to systemic therapy-associated caveats such a...

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Vydáno v:Neuro Oncol
Hlavní autoři: Smith, Stuart, Serra, Riccardo, Rowlinson, Jonathan, Gorelick, Noah, Veal, Gareth, Shakesheff, Kevin, Brem, Henry, Grundy, Richard, Tyler, Betty, Rahman, Ruman
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6789660/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz167.007
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