SCIDOT-32. NEUROSURGICAL DELIVERY OF THE POLY ADP RIBOSE POLYMERASE-1 INHIBITOR OLAPARIB FROM A THERMO-RESPONSIVE BIODEGRADABLE PASTE POTENTIATES RADIOTHERAPY AND PROLONGS SURVIVAL IN HIGH-GRADE GLIOMA

There has been considerable interest in repurposing the poly ADP ribose polymerase inhibitor and purported radiosensitiser olaparib (Lynparza), with a recent dose escalation study of olaparib plus temozolomide in recurrent GBM showing good tolerance (Fulton et al 2018). Due to systemic therapy-assoc...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Smith, Stuart, Serra, Riccardo, Rowlinson, Jonathan, Gorelick, Noah, Veal, Gareth, Shakesheff, Kevin, Brem, Henry, Grundy, Richard, Tyler, Betty, Rahman, Ruman
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Abstracts from the 3rd Sno-Scidot Joint Conference on Therapeutic Delivery to the CNS
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6846760/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.1168
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