μ-Conotoxin PIIIA, a New Peptide for Discriminating among Tetrodotoxin-Sensitive Na Channel Subtypes

We report the characterization of a new sodium channel blocker, μ-conotoxin PIIIA (μ-PIIIA). The peptide has been synthesized chemically and its disulfide bridging pattern determined. The structure of the new peptide is: where Z = pyroglutamate andO = 4-trans-hydroxyproline. We demonstrate that Argi...

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Publicado no:J Neurosci
Main Authors: Shon, Ki-Joon, Olivera, Baldomero M., Watkins, Maren, Jacobsen, Richard B., Gray, William R., Floresca, Christina Z., Cruz, Lourdes J., Hillyard, David R., Brink, Anette, Terlau, Heinrich, Yoshikami, Doju
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1998
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792697/
https://ncbi.nlm.nih.gov/pubmed/9614224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-12-04473.1998
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