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Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.
Overexpression and altered metabolism of amyloid precursor protein (APP) resulting in increased 4 kDa amyloid β peptide (Aβ) production are believed to play a major role in Alzheimer’s disease (AD). Therefore, reducing Aβ production in the brain is a possible therapy for AD. Because AD pathology is...
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| Publicado no: | J Neurosci |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Neuroscience
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6792603/ https://ncbi.nlm.nih.gov/pubmed/9526007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-08-02907.1998 |
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