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Protein Kinase C Activation Increases Release of Secreted Amyloid Precursor Protein without Decreasing Aβ Production in Human Primary Neuron Cultures.

Overexpression and altered metabolism of amyloid precursor protein (APP) resulting in increased 4 kDa amyloid β peptide (Aβ) production are believed to play a major role in Alzheimer’s disease (AD). Therefore, reducing Aβ production in the brain is a possible therapy for AD. Because AD pathology is...

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Vydáno v:J Neurosci
Hlavní autoři: LeBlanc, Andréa C., Koutroumanis, Maria, Goodyer, Cynthia G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792603/
https://ncbi.nlm.nih.gov/pubmed/9526007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.18-08-02907.1998
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