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Selective cytotoxicity of intracellular amyloid β peptide(1–42) through p53 and Bax in cultured primary human neurons

Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ(1–42) accumulation before extracellular Aβ deposits questions the relevance of intracellular peptides in AD. In the present study, we dire...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhang, Yan, McLaughlin, Richard, Goodyer, Cynthia, LeBlanc, Andréa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2002
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173346/
https://ncbi.nlm.nih.gov/pubmed/11815632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200110119
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