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Selective cytotoxicity of intracellular amyloid β peptide(1–42) through p53 and Bax in cultured primary human neurons

Extracellular amyloid β peptides (Aβs) have long been thought to be a primary cause of Alzheimer's disease (AD). Now, detection of intracellular neuronal Aβ(1–42) accumulation before extracellular Aβ deposits questions the relevance of intracellular peptides in AD. In the present study, we dire...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Yan, McLaughlin, Richard, Goodyer, Cynthia, LeBlanc, Andréa
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2002
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173346/
https://ncbi.nlm.nih.gov/pubmed/11815632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200110119
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