Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid β-peptide-independent neuronal degeneration in primary human neuron cultures.

Although familial Alzheimer disease (AD)-associated autosomal dominant mutants have been extensively studied, little is known about the underlying molecular mechanisms of neurodegeneration induced by these mutants in AD. Wild-type, Swedish or London amyloid precursor protein (APP) transfection in pr...

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Autores principales: Sivananthan, S N, Lee, A W, Goodyer, C G, LeBlanc, A C
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2010
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3032318/
https://ncbi.nlm.nih.gov/pubmed/21368865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2010.74
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