Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid β(1-42) Toxicity through Heat Shock Protein 70

Intracellular amyloidβ peptide (iAβ(1-42)) accumulates in the Alzheimer's disease brain before plaque and tangle formation (Gouras et al., 2000) and is extremely toxic to human neurons (Zhang et al., 2002). Here, we investigated whether androgen and estrogen could prevent iAβ(1-42) toxicity, be...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhang, Yan, Champagne, Nathalie, Beitel, Lenore K., Goodyer, Cynthia G., Trifiro, Mark, LeBlanc, Andréa
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2004
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729301/
https://ncbi.nlm.nih.gov/pubmed/15190103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0913-04.2004
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