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Estrogen and Androgen Protection of Human Neurons against Intracellular Amyloid β(1-42) Toxicity through Heat Shock Protein 70

Intracellular amyloidβ peptide (iAβ(1-42)) accumulates in the Alzheimer's disease brain before plaque and tangle formation (Gouras et al., 2000) and is extremely toxic to human neurons (Zhang et al., 2002). Here, we investigated whether androgen and estrogen could prevent iAβ(1-42) toxicity, be...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Zhang, Yan, Champagne, Nathalie, Beitel, Lenore K., Goodyer, Cynthia G., Trifiro, Mark, LeBlanc, Andréa
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729301/
https://ncbi.nlm.nih.gov/pubmed/15190103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0913-04.2004
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