Prdx4 limits caspase‐1 activation and restricts inflammasome‐mediated signaling by extracellular vesicles

Inflammasomes are cytosolic protein complexes, which orchestrate the maturation of active IL‐1β by proteolytic cleavage via caspase‐1. Although many principles of inflammasome activation have been described, mechanisms that limit inflammasome‐dependent immune responses remain poorly defined. Here, w...

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Pubblicato in:EMBO J
Autori principali: Lipinski, Simone, Pfeuffer, Steffen, Arnold, Philipp, Treitz, Christian, Aden, Konrad, Ebsen, Henriette, Falk‐Paulsen, Maren, Gisch, Nicolas, Fazio, Antonella, Kuiper, Jan, Luzius, Anne, Billmann‐Born, Susanne, Schreiber, Stefan, Nuñez, Gabriel, Beer, Hans‐Dietmar, Strowig, Till, Lamkanfi, Mohamed, Tholey, Andreas, Rosenstiel, Philip
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792017/
https://ncbi.nlm.nih.gov/pubmed/31544965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101266
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