Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

BACKGROUND & AIMS: Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regulate ATF6 and its role for...

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Publié dans:Gastroenterology
Auteurs principaux: Stengel, Stephanie T., Fazio, Antonella, Lipinski, Simone, Jahn, Martin T., Aden, Konrad, Ito, Go, Wottawa, Felix, Kuiper, Jan W.P., Coleman, Olivia I., Tran, Florian, Bordoni, Dora, Bernardes, Joana P., Jentzsch, Marlene, Luzius, Anne, Bierwirth, Sandra, Messner, Berith, Henning, Anna, Welz, Lina, Kakavand, Nassim, Falk-Paulsen, Maren, Imm, Simon, Hinrichsen, Finn, Zilbauer, Matthias, Schreiber, Stefan, Kaser, Arthur, Blumberg, Richard, Haller, Dirk, Rosenstiel, Philip
Format: Artigo
Langue:Inglês
Publié: 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923714/
https://ncbi.nlm.nih.gov/pubmed/32673694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.06.088
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