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Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress

BACKGROUND & AIMS: Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regulate ATF6 and its role for...

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Publicado no:Gastroenterology
Main Authors: Stengel, Stephanie T., Fazio, Antonella, Lipinski, Simone, Jahn, Martin T., Aden, Konrad, Ito, Go, Wottawa, Felix, Kuiper, Jan W.P., Coleman, Olivia I., Tran, Florian, Bordoni, Dora, Bernardes, Joana P., Jentzsch, Marlene, Luzius, Anne, Bierwirth, Sandra, Messner, Berith, Henning, Anna, Welz, Lina, Kakavand, Nassim, Falk-Paulsen, Maren, Imm, Simon, Hinrichsen, Finn, Zilbauer, Matthias, Schreiber, Stefan, Kaser, Arthur, Blumberg, Richard, Haller, Dirk, Rosenstiel, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923714/
https://ncbi.nlm.nih.gov/pubmed/32673694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2020.06.088
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