Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation

A plethora of functional and genetic studies have suggested a key role for the IL-23 pathway in chronic intestinal inflammation. Currently, pathogenic actions of IL-23 have been ascribed to specific effects on immune cells. Herein, we unveil a protective role of IL-23R signaling. Mice deficient in I...

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Publicado en:Cell Rep
Autores principales: Aden, Konrad, Rehman, Ateequr, Falk-Paulsen, Maren, Secher, Thomas, Kuiper, Jan, Tran, Florian, Pfeuffer, Steffen, Sheibani-Tezerji, Raheleh, Breuer, Alexandra, Luzius, Anne, Jentzsch, Marlene, Häsler, Robert, Billmann-Born, Susanne, Will, Olga, Lipinski, Simone, Bharti, Richa, Adolph, Timon, Iovanna, Juan L., Kempster, Sarah L., Blumberg, Richard S., Schreiber, Stefan, Becher, Burkhard, Chamaillard, Mathias, Kaser, Arthur, Rosenstiel, Philip
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5443566/
https://ncbi.nlm.nih.gov/pubmed/27524624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.054
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