RNAi screening identifies mediators of NOD2 signaling: Implications for spatial specificity of MDP recognition

The intracellular nucleotide-binding oligomerization domain-2 (NOD2) receptor detects bacteria-derived muramyl dipeptide (MDP) and activates the transcription factor NF-κB. Here we describe the regulatome of NOD2 signaling using a systematic RNAi screen. Using three consecutive screens, we identifie...

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Bibliografiske detaljer
Main Authors: Lipinski, Simone, Grabe, Nils, Jacobs, Gunnar, Billmann-Born, Susanne, Till, Andreas, Häsler, Robert, Aden, Konrad, Paulsen, Maren, Arlt, Alexander, Kraemer, Lars, Hagemann, Nina, Erdmann, Kai Sven, Schreiber, Stefan, Rosenstiel, Philip
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535590/
https://ncbi.nlm.nih.gov/pubmed/23213202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209673109
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