E2F1 proteolysis via SCF‐cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition

Cyclins are central engines of cell cycle progression in conjunction with cyclin‐dependent kinases (CDKs). Among the different cyclins controlling cell cycle progression, cyclin F does not partner with a CDK, but instead forms via its F‐box domain an SCF (Skp1‐Cul1‐F‐box)‐type E3 ubiquitin ligase mo...

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Pubblicato in:EMBO J
Autori principali: Burdova, Kamila, Yang, Hongbin, Faedda, Roberta, Hume, Samuel, Chauhan, Jagat, Ebner, Daniel, Kessler, Benedikt M, Vendrell, Iolanda, Drewry, David H, Wells, Carrow I, Hatch, Stephanie B, Dianov, Grigory L, Buffa, Francesca M, D'Angiolella, Vincenzo
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6792013/
https://ncbi.nlm.nih.gov/pubmed/31424118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018101443
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