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grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events

The Drosophila grapes (grp) gene, which encodes a homolog of the Schizosaccharomyces pombe Chk1 kinase, provides a cell-cycle checkpoint that delays mitosis in response to inhibition of DNA replication (Au: OK?) [1]. Grp is also required in the undisturbed early embryonic cycles: in its absence, mit...

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Detalhes bibliográficos
Main Authors: Su, Tin Tin, Campbell, Shelagh D., O’Farrell, Patrick H.
Formato: Artigo
Idioma:Inglês
Publicado em: 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749710/
https://ncbi.nlm.nih.gov/pubmed/10469601
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