Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

Relapse remains the main cause of MLL-rearranged (MLL-r) acute lymphoblastic leukemia (ALL) treatment failure resulting from persistence of drug-resistant clones after conventional chemotherapy treatment or targeted therapy. Thus, defining mechanisms underlying MLL-r ALL maintenance is critical for...

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Veröffentlicht in:Blood
Hauptverfasser: Zhu, Yinghui, He, Xin, Lin, Yi-Chun, Dong, Haojie, Zhang, Lei, Chen, Xianwei, Wang, Zhihao, Shen, Yudao, Li, Min, Wang, Hanying, Sun, Jie, Nguyen, Le Xuan, Zhang, Han, Jiang, Wenjuan, Yang, Yanzhong, Chen, Jianjun, Müschen, Markus, Chen, Chun-Wei, Konopleva, Marina Y., Sun, Weili, Jin, Jian, Carlesso, Nadia, Marcucci, Guido, Luo, Yun, Li, Ling
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2019
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6788006/
https://ncbi.nlm.nih.gov/pubmed/31395602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002457
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