PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD(+) acute myeloid leukemia

The presence of FMS-like receptor tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutations in patients with acute myeloid leukemia (AML) is associated with poor clinical outcome. FLT3 tyrosine kinase inhibitors (TKIs), although effective in kinase ablation, do not eliminate primitive FLT3-...

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Vydáno v:Blood
Hlavní autoři: He, Xin, Zhu, Yinghui, Lin, Yi-Chun, Li, Min, Du, Juan, Dong, Haojie, Sun, Jie, Zhu, Lei, Wang, Hanying, Ding, Zonghui, Zhang, Lei, Zhang, Lianjun, Zhao, Dandan, Wang, Zhihao, Wu, Herman, Zhang, Han, Jiang, Wenjuan, Xu, Yang, Jin, Jian, Shen, Yudao, Perry, Jeff, Zhao, Xinyang, Zhang, Bin, Liu, Songbai, Xue, Sheng-Li, Shen, Binghui, Chen, Chun-Wei, Chen, Jianjun, Khaled, Samer, Kuo, Ya-Huei, Marcucci, Guido, Luo, Yun, Li, Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2019
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6688430/
https://ncbi.nlm.nih.gov/pubmed/31217189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019001282
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