Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis

Glioblastoma (GBM) is the most prevalent malignant tumor in the central nervous system. Aerobic glycolysis, featured with elevated glucose consumption and lactate production, confers selective advantages on GBM by utilizing nutrients to support rapid cell proliferation and tumor growth. Pyruvate kin...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Guo, Jianshuang, Xue, Qingqing, Liu, Kaihui, Ge, Weizhi, Liu, Wenjie, Wang, Jiyan, Zhang, Mengyi, Li, Qiu-ying, Cai, Dongpo, Shan, Changliang, Zhang, Chunze, Liu, Xinqi, Li, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783512/
https://ncbi.nlm.nih.gov/pubmed/31632919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00993
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