Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

Pyruvate kinase M2 (PKM2) is a key player in the Warburg effect of cancer cells. However, the mechanisms of regulating PKM2 are not fully elucidated. Here, we identified the protein-serine/threonine kinase PIM2, a known oncogene, as a novel binding partner of PKM2. The interaction between PIM2 and P...

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Detalhes bibliográficos
Main Authors: Yu, Zhenhai, Zhao, Xiaoping, Huang, Liangqian, Zhang, Teng, Yang, Fajun, Xie, Lei, Song, Shaoli, Miao, Ping, Zhao, Li, Sun, Xiaoguang, Liu, Jianjun, Huang, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853288/
https://ncbi.nlm.nih.gov/pubmed/24142698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508226
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