immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

Protein-based therapeutics can activate the adaptive immune system and lead to the production of neutralizing antibodies and to cytotoxic-T-cell-mediated clearance of the treated cells. Here, we show that the sequential use of immune-orthogonal orthologues of the CRISPR-associated protein 9 (Cas9) a...

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Gepubliceerd in:Nat Biomed Eng
Hoofdauteurs: Moreno, Ana M., Palmer, Nathan, Alemán, Fernando, Chen, Genghao, Pla, Andrew, Jiang, Ning, Chew, Wei Leong, Law, Mansun, Mali, Prashant
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6783354/
https://ncbi.nlm.nih.gov/pubmed/31332341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41551-019-0431-2
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