Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21(waf1/cip1), and Erythropoietin

Iron chelators are pluripotent neuronal antiapoptotic agents that have been shown to enhance metabolic recovery in cerebral ischemia models. The precise mechanism(s) by which these agents exert their effects remains unclear. Recent studies have demonstrated that iron chelators activate a hypoxia sig...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:J Neurosci
المؤلفون الرئيسيون: Zaman, Khalequz, Ryu, Hoon, Hall, David, O'Donovan, Kevin, Lin, Kuo-I, Miller, Matthew P., Marquis, John C., Baraban, Jay M., Semenza, Gregg L., Ratan, Rajiv R.
التنسيق: Artigo
اللغة:Inglês
منشور في: Society for Neuroscience 1999
الموضوعات:
ARTICLE
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782985/
https://ncbi.nlm.nih.gov/pubmed/10559391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-22-09821.1999
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