A screen for inducers of p21 (waf1/cip1) identifies HIF prolyl hydroxylase inhibitors as neuroprotective agents with antitumor properties

Preventing neuronal death is a priority for treating neurological diseases. However, therapies that inhibit pathological neuron loss could promote tumorigenesis by preventing the physiological death of cancerous cells. To avert this, we targeted the transcriptional upregulation of p21(waf1/cip1) (p2...

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Библиографические подробности
Главные авторы: Ma, Thong C., Langley, Brett, Ko, Brian, Wei, Na, Gazaryan, Irina G., Zareen, Neela, Yamashiro, Darrell J., Willis, Dianna E., Ratan, Rajiv R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3706502/
https://ncbi.nlm.nih.gov/pubmed/22944173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.08.016
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