Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model

A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures. Neuradapt activates the expression of HIF1 and HIF2...

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Udgivet i:Antioxidants (Basel)
Main Authors: Savyuk, Maria, Krivonosov, Mikhail, Mishchenko, Tatiana, Gazaryan, Irina, Ivanchenko, Mikhail, Khristichenko, Anna, Poloznikov, Andrey, Hushpulian, Dmitry, Nikulin, Sergey, Tonevitsky, Evgeny, Abuzarova, Guzal, Mitroshina, Elena, Vedunova, Maria
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463909/
https://ncbi.nlm.nih.gov/pubmed/32722310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9080662
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