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Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model

A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures. Neuradapt activates the expression of HIF1 and HIF2...

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Dades bibliogràfiques
Publicat a:Antioxidants (Basel)
Autors principals: Savyuk, Maria, Krivonosov, Mikhail, Mishchenko, Tatiana, Gazaryan, Irina, Ivanchenko, Mikhail, Khristichenko, Anna, Poloznikov, Andrey, Hushpulian, Dmitry, Nikulin, Sergey, Tonevitsky, Evgeny, Abuzarova, Guzal, Mitroshina, Elena, Vedunova, Maria
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463909/
https://ncbi.nlm.nih.gov/pubmed/32722310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9080662
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