Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model

A novel potent analog of the branched tail oxyquinoline group of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors, neuradapt, has been studied in two treatment regimes in an in vitro hypoxia model on murine primary hippocampal cultures. Neuradapt activates the expression of HIF1 and HIF2...

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Pubblicato in:Antioxidants (Basel)
Autori principali: Savyuk, Maria, Krivonosov, Mikhail, Mishchenko, Tatiana, Gazaryan, Irina, Ivanchenko, Mikhail, Khristichenko, Anna, Poloznikov, Andrey, Hushpulian, Dmitry, Nikulin, Sergey, Tonevitsky, Evgeny, Abuzarova, Guzal, Mitroshina, Elena, Vedunova, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463909/
https://ncbi.nlm.nih.gov/pubmed/32722310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9080662
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