Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21(waf1/cip1), and Erythropoietin

Iron chelators are pluripotent neuronal antiapoptotic agents that have been shown to enhance metabolic recovery in cerebral ischemia models. The precise mechanism(s) by which these agents exert their effects remains unclear. Recent studies have demonstrated that iron chelators activate a hypoxia sig...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zaman, Khalequz, Ryu, Hoon, Hall, David, O'Donovan, Kevin, Lin, Kuo-I, Miller, Matthew P., Marquis, John C., Baraban, Jay M., Semenza, Gregg L., Ratan, Rajiv R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 1999
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782985/
https://ncbi.nlm.nih.gov/pubmed/10559391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-22-09821.1999
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