The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures

The amyloid precursor protein (APP) of Alzheimer's disease can reduce copper (II) to copper (I) in a cell-free system potentially leading to increased oxidative stress in neurons. We used neuronal cultures derived from APP knock-out (APP(−/−)) and wild-type (WT) mice to examine the role of APP...

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Publicado en:J Neurosci
Autores principales: White, Anthony R., Multhaup, Gerd, Maher, Fran, Bellingham, Shayne, Camakaris, James, Zheng, Hui, Bush, Ashley I., Beyreuther, Konrad, Masters, Colin L., Cappai, Roberto
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 1999
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6782934/
https://ncbi.nlm.nih.gov/pubmed/10531420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.19-21-09170.1999
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