Copper inhibits beta-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion.

Previous studies have demonstrated that amyloid precursor protein (APP) can bind and reduce Cu(II) to Cu(I), leading to oxidative modification of APP. In the present study we show that adding copper to Chinese-hamster ovary (CHO) cells greatly reduced the levels of amyloid Abeta peptide (Abeta) both...

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Main Authors: Borchardt, T, Camakaris, J, Cappai, R, Masters, C L, Beyreuther, K, Multhaup, G
格式: Artigo
語言:Inglês
出版: 1999
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220664/
https://ncbi.nlm.nih.gov/pubmed/10567229
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