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Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway
BACKGROUND: Icaritin (ICT) is a prenylflavonoid derivative from Epimedium brevicornum Maxim. ICT has been shown to have neuroprotective effects. We investigate how ICT affects secretion of amyloid precursor protein (APP). METHODS: We exposed APP-PS1-HEK293 cells to ICT to investigate its effect on b...
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| Publicado no: | PeerJ |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
PeerJ Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910110/ https://ncbi.nlm.nih.gov/pubmed/31844591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.8219 |
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