Disrupted-in-Schizophrenia-1 Attenuates Amyloid-β Generation and Cognitive Deficits in APP/PS1 Transgenic Mice by Reduction of β-Site APP-Cleaving Enzyme 1 Levels

Disrupted-in-Schizophrenia-1 (DISC1) is a genetic risk factor for a wide range of major mental disorders, including schizophrenia, major depression, and bipolar disorders. Recent reports suggest a potential role of DISC1 in the pathogenesis of Alzheimer's disease (AD), by referring to an intera...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Deng, Qing-Shan, Dong, Xing-Yu, Wu, Hao, Wang, Wang, Wang, Zhao-Tao, Zhu, Jian-Wei, Liu, Chun-Feng, Jia, Wei-Qiang, Zhang, Yan, Schachner, Melitta, Ma, Quan-Hong, Xu, Ru-Xiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130120/
https://ncbi.nlm.nih.gov/pubmed/26062786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.164
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