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Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase
Telomeres progressively shorten at every round of DNA replication in the absence of telomerase. When they become critically short, telomeres trigger replicative senescence by activating a DNA damage response that is governed by the Mec1/ATR and Tel1/ATM protein kinases. While Mec1/ATR is known to bl...
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| Published in: | Genetics |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Genetics Society of America
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6781906/ https://ncbi.nlm.nih.gov/pubmed/31391264 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302391 |
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