MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation

Drug metabolizing enzymes mediate biotransformation of drugs and play an essential role in drug efficacy and toxicity. Human sulfotransferases are a superfamily of Phase II detoxification enzymes that metabolize a wide spectrum of endogenous compounds and xenobiotics. SULT2A1 is one of the most abun...

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Bibliografiset tiedot
Julkaisussa:Biochem Pharmacol
Päätekijät: Li, Dongying, Knox, Bridgett, Chen, Si, Wu, Leihong, Tolleson, William H., Liu, Zhichao, Yu, Dianke, Guo, Lei, Tong, Weida, Ning, Baitang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6779501/
https://ncbi.nlm.nih.gov/pubmed/31445882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2019.08.019
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